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Aralkylamine ''N''-acetyltransferase (AANAT) (), also known as arylalkylamine ''N''-acetyltransferase or serotonin ''N''-acetyltransferase (SNAT), is an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. It is in humans encoded by the ~2.5 kb ''AANAT'' gene〔(【引用サイトリンク】 url =http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=15 )〕 containing four exons, located on chromosome 17q25. The gene is translated into a 23 kDa large enzyme. It is well conserved through evolution and the human form of the protein is 80% identical to sheep and rat AANAT. It is an acetyl-CoA-dependent enzyme of the GCN5-related family of ''N''-acetyltransferases (GNATs). It may contribute to multifactorial genetic diseases such as altered behavior in sleep/wake cycle〔 and research is on-going with the aim of developing drugs that regulate AANAT function. == Nomenclature == The systematic name of this enzyme class is acetyl-CoA:2-arylethylamine N-acetyltransferase. Other names in common use include: * AANAT * Arylalkylamine N-acetyltransferase * Melatonin rhythm enzyme * Serotonin acetylase * Serotonin acetyltransferase * Serotonin N-acetyltransferase The officially accepted name is aralkylamine N-acetyltransferase.〔(【引用サイトリンク】url=http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/3/1/87.html )〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Aralkylamine N-acetyltransferase」の詳細全文を読む スポンサード リンク
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